Recently speaking with MTV during the promotion for the upcoming The Expendables 3 release, Wesley Snipes was asked if he'd consider reprising his role in Blade, and Snipes was very enthusiastic about the idea;
"I’d be open to it. I think we’ve got some stones left unturned and there’s some latitude left for us to build on and I’d love to get back in the suit again and do some things I’ve learned how to do now that I didn’t know how to do then. I think we’re better at making that kind of a film now. Some of the things we did in the early parts of the franchise were experimental and now they’ve become customary in a lot of the Avengers films and other comic book adaptations."